Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Prox1  prospero homeobox 1   (Synonyms: A230003G05Rik)
Results	Reference
1	J:254591 Alldredge A, Fuhrmann S, Loss of Axin2 Causes Ocular Defects During Mouse Eye Development. Invest Ophthalmol Vis Sci. 2016 Oct 1;57(13):5253-5262
1	J:251150 Aoki H, Ogino H, Tomita H, Hara A, Kunisada T, Disruption of Rest Leads to the Early Onset of Cataracts with the Aberrant Terminal Differentiation of Lens Fiber Cells. PLoS One. 2016;11(9):e0163042
1	J:79852 Bagri A, Gurney T, He X, Zou YR, Littman DR, Tessier-Lavigne M, Pleasure SJ, The chemokine SDF1 regulates migration of dentate granule cells. Development. 2002 Sep;129(18):4249-60
1	J:269938 Bovay E, Sabine A, Prat-Luri B, Kim S, Son K, Willrodt AH, Olsson C, Halin C, Kiefer F, Betsholtz C, Jeon NL, Luther SA, Petrova TV, Multiple roles of lymphatic vessels in peripheral lymph node development. J Exp Med. 2018 Nov 5;215(11):2760-2777
1	J:302526 Cao X, An J, Cao Y, Lv J, Wang J, Ding Y, Lin X, Zhou X, EMC3 Is Essential for Retinal Organization and Neurogenesis During Mouse Retinal Development. Invest Ophthalmol Vis Sci. 2021 Feb 1;62(2):31
1	J:233304 Cha B, Geng X, Mahamud MR, Fu J, Mukherjee A, Kim Y, Jho EH, Kim TH, Kahn ML, Xia L, Dixon JB, Chen H, Srinivasan RS, Mechanotransduction activates canonical Wnt/beta-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves. Genes Dev. 2016 Jun 15;30(12):1454-69
1	J:269779 Cha B, Geng X, Mahamud MR, Zhang JY, Chen L, Kim W, Jho EH, Kim Y, Choi D, Dixon JB, Chen H, Hong YK, Olson L, Kim TH, Merrill BJ, Davis MJ, Srinivasan RS, Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wnt/beta-Catenin Signaling. Cell Rep. 2018 Oct 16;25(3):571-584.e5
1	J:301556 Cha B, Ho YC, Geng X, Mahamud MR, Chen L, Kim Y, Choi D, Kim TH, Randolph GJ, Cao X, Chen H, Srinivasan RS, YAP and TAZ maintain PROX1 expression in the developing lymphatic and lymphovenous valves in response to VEGF-C signaling. Development. 2020 Dec 13;147(23):dev195453
1	J:142229 Dabdoub A, Puligilla C, Jones JM, Fritzsch B, Cheah KS, Pevny LH, Kelley MW, Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea. Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18396-401
1	J:188626 Dicke N, Pielensticker N, Degen J, Hecker J, Tress O, Bald T, Gellhaus A, Winterhager E, Willecke K, Peripheral lymphangiogenesis in mice depends on ectodermal connexin-26 (Gjb2). J Cell Sci. 2011 Aug 15;124(Pt 16):2806-15
1	J:134563 Elshatory Y, Deng M, Xie X, Gan L, Expression of the LIM-homeodomain protein Isl1 in the developing and mature mouse retina. J Comp Neurol. 2007 Jul 1;503(1):182-97
1	J:238230 Furlan A, La Manno G, Lubke M, Haring M, Abdo H, Hochgerner H, Kupari J, Usoskin D, Airaksinen MS, Oliver G, Linnarsson S, Ernfors P, Visceral motor neuron diversity delineates a cellular basis for nipple- and pilo-erection muscle control. Nat Neurosci. 2016 Oct;19(10):1331-40
1	J:134976 Galichet C, Guillemot F, Parras CM, Neurogenin 2 has an essential role in development of the dentate gyrus. Development. 2008 Jun;135(11):2031-41
1*	J:139639 Juszynski M, Ciszek B, Stachurska E, Jablonska A, Ratajska A, Development of lymphatic vessels in mouse embryonic and early postnatal hearts. Dev Dyn. 2008 Sep 24;237(10):2973-2986
1	J:320186 Kalisch-Smith JI, Morris EC, Strevens MAA, Redpath AN, Klaourakis K, Szumska D, Outhwaite JE, Sun X, Vieira JM, Smart N, De Val S, Riley PR, Sparrow DB, Analysis of Placental Arteriovenous Formation Reveals New Insights Into Embryos With Congenital Heart Defects. Front Genet. 2021;12:806136
1	J:196835 Kerr CL, Huang J, Williams T, West-Mays JA, Activation of the hedgehog signaling pathway in the developing lens stimulates ectopic FoxE3 expression and disruption in fiber cell differentiation. Invest Ophthalmol Vis Sci. 2012 Jun;53(7):3316-30
1*	J:122404 Kim KE, Sung HK, Koh GY, Lymphatic development in mouse small intestine. Dev Dyn. 2007 Jul;236(7):2020-5
1*	J:141989 Kirjavainen A, Sulg M, Heyd F, Alitalo K, Yla-Herttuala S, Moroy T, Petrova TV, Pirvola U, Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia. Dev Biol. 2008 Oct 1;322(1):33-45
1	J:203109 Konno D, Iwashita M, Satoh Y, Momiyama A, Abe T, Kiyonari H, Matsuzaki F, The mammalian DM domain transcription factor Dmrta2 is required for early embryonic development of the cerebral cortex. PLoS One. 2012;7(10):e46577
1	J:121794 Kreslova J, Machon O, Ruzickova J, Lachova J, Wawrousek EF, Kemler R, Krauss S, Piatigorsky J, Kozmik Z, Abnormal lens morphogenesis and ectopic lens formation in the absence of beta-catenin function. Genesis. 2007 Apr;45(4):157-68
1	J:181400 Kuracha MR, Burgess D, Siefker E, Cooper JT, Licht JD, Robinson ML, Govindarajan V, Spry1 and Spry2 are necessary for lens vesicle separation and corneal differentiation. Invest Ophthalmol Vis Sci. 2011 Aug;52(9):6887-97
1	J:143512 Li G, Kataoka H, Coughlin SR, Pleasure SJ, Identification of a transient subpial neurogenic zone in the developing dentate gyrus and its regulation by Cxcl12 and reelin signaling. Development. 2009 Jan;136(2):327-35
1	J:256014 Lin YC, Ohbayashi N, Hongu T, Katagiri N, Funakoshi Y, Lee H, Kanaho Y, Arf6 in lymphatic endothelial cells regulates lymphangiogenesis by controlling directional cell migration. Sci Rep. 2017 Sep 12;7(1):11431
1	J:332090 Lioux G, Liu X, Temino S, Oxendine M, Ayala E, Ortega S, Kelly RG, Oliver G, Torres M, A Second Heart Field-Derived Vasculogenic Niche Contributes to Cardiac Lymphatics. Dev Cell. 2020 Feb 10;52(3):350-363.e6
1*	J:310860 Liu S, Wang Y, Lu Y, Li W, Liu W, Ma J, Sun F, Li M, Chen ZY, Su K, Li W, The Key Transcription Factor Expression in the Developing Vestibular and Auditory Sensory Organs: A Comprehensive Comparison of Spatial and Temporal Patterns. Neural Plast. 2018;2018:7513258
1	J:189960 Madakashira BP, Kobrinski DA, Hancher AD, Arneman EC, Wagner BD, Wang F, Shin H, Lovicu FJ, Reneker LW, Robinson ML, Frs2alpha enhances fibroblast growth factor-mediated survival and differentiation in lens development. Development. 2012 Dec;139(24):4601-12
1	J:284120 Mahamud MR, Geng X, Ho YC, Cha B, Kim Y, Ma J, Chen L, Myers G, Camper S, Mustacich D, Witte M, Choi D, Hong YK, Chen H, Varshney G, Engel JD, Wang S, Kim TH, Lim KC, Srinivasan RS, GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis through miR-126. Development. 2019 Nov 5;146(21):dev184218
1	J:180117 Nasonkin IO, Lazo K, Hambright D, Brooks M, Fariss R, Swaroop A, Distinct nuclear localization patterns of DNA methyltransferases in developing and mature mammalian retina. J Comp Neurol. 2011 Jul 1;519(10):1914-30
1	J:178908 Okano T, Xuan S, Kelley MW, Insulin-like growth factor signaling regulates the timing of sensory cell differentiation in the mouse cochlea. J Neurosci. 2011 Dec 7;31(49):18104-18
1	J:255744 Rhee S, Chung JI, King DA, D'amato G, Paik DT, Duan A, Chang A, Nagelberg D, Sharma B, Jeong Y, Diehn M, Wu JC, Morrison AJ, Red-Horse K, Endothelial deletion of Ino80 disrupts coronary angiogenesis and causes congenital heart disease. Nat Commun. 2018 Jan 25;9(1):368
1	J:333399 Rhee S, Paik DT, Yang JY, Nagelberg D, Williams I, Tian L, Roth R, Chandy M, Ban J, Belbachir N, Kim S, Zhang H, Phansalkar R, Wong KM, King DA, Valdez C, Winn VD, Morrison AJ, Wu JC, Red-Horse K, Endocardial/endothelial angiocrines regulate cardiomyocyte development and maturation and induce features of ventricular non-compaction. Eur Heart J. 2021 Nov 1;42(41):4264-4276
1	J:310007 Ryan AR, England AR, Chaney CP, Cowdin MA, Hiltabidle M, Daniel E, Gupta AK, Oxburgh L, Carroll TJ, Cleaver O, Vascular deficiencies in renal organoids and ex vivo kidney organogenesis. Dev Biol. 2021 Sep;477:98-116
1	J:181330 Sabine A, Agalarov Y, Maby-El Hajjami H, Jaquet M, Hagerling R, Pollmann C, Bebber D, Pfenniger A, Miura N, Dormond O, Calmes JM, Adams RH, Makinen T, Kiefer F, Kwak BR, Petrova TV, Mechanotransduction, PROX1, and FOXC2 Cooperate to Control Connexin37 and Calcineurin during Lymphatic-Valve Formation. Dev Cell. 2012 Feb 14;22(2):430-45
1	J:223633 Sanchez-Calderon H, Rodriguez-de la Rosa L, Milo M, Pichel JG, Holley M, Varela-Nieto I, RNA microarray analysis in prenatal mouse cochlea reveals novel IGF-I target genes: implication of MEF2 and FOXM1 transcription factors. PLoS One. 2010;5(1):e8699
1	J:115522 Sandilands A, Hutcheson AM, Long HA, Prescott AR, Vrensen G, Loster J, Klopp N, Lutz RB, Graw J, Masaki S, Dobson CM, MacPhee CE, Quinlan RA, Altered aggregation properties of mutant gamma-crystallins cause inherited cataract. EMBO J. 2002 Nov 15;21(22):6005-14
1	J:208341 Seth A, Ye J, Yu N, Guez F, Bedford DC, Neale GA, Cordi S, Brindle PK, Lemaigre FP, Kaestner KH, Sosa-Pineda B, Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment. Development. 2014 Feb;141(3):538-47
1	J:137035 Solberg N, Machon O, Krauss S, Effect of canonical Wnt inhibition in the neurogenic cortex, hippocampus, and premigratory dentate gyrus progenitor pool. Dev Dyn. 2008 Jul;237(7):1799-811
1	J:177488 Srinivasan RS, Oliver G, Prox1 dosage controls the number of lymphatic endothelial cell progenitors and the formation of the lymphovenous valves. Genes Dev. 2011 Oct 15;25(20):2187-97
1	J:278572 Stone OA, Stainier DYR, Paraxial Mesoderm Is the Major Source of Lymphatic Endothelium. Dev Cell. 2019 Jul 22;50(2):247-255.e3
1	J:171468 Tateya T, Imayoshi I, Tateya I, Ito J, Kageyama R, Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development. Dev Biol. 2011 Apr 15;352(2):329-40
1*	J:248338 Teoh JJ, Iwano T, Kunii M, Atik N, Avriyanti E, Yoshimura SI, Moriwaki K, Harada A, BIG1 is required for the survival of deep layer neurons, neuronal polarity, and the formation of axonal tracts between the thalamus and neocortex in developing brain. PLoS One. 2017;12(4):e0175888
1	J:237527 Thein T, de Melo J, Zibetti C, Clark BS, Juarez F, Blackshaw S, Control of lens development by Lhx2-regulated neuroretinal FGFs. Development. 2016 Nov 01;143(21):3994-4002
1	J:215000 Turner CJ, Badu-Nkansah K, Crowley D, van der Flier A, Hynes RO, Integrin-alpha5beta1 is not required for mural cell functions during development of blood vessels but is required for lymphatic-blood vessel separation and lymphovenous valve formation. Dev Biol. 2014 Aug 15;392(2):381-92
1	J:319651 Yamada M, Clark J, McClelland C, Capaldo E, Ray A, Iulianella A, Cux2 activity defines a subpopulation of perinatal neurogenic progenitors in the hippocampus. Hippocampus. 2015 Feb;25(2):253-67